Wood CW, Walter E, Espinosa C, Enriquez-Bruce ME, Budhecha S, Elliott A, Domachowske J,…, Suh M, et al. Results from four US health systems: (1) Seasonality of infant lower respiratory tract infections, including those caused by RSV, was altered during the COVID-19 pandemic; and (2) Infant hospitalizations and ICU admissions for bronchiolitis and RSV-bronchiolitis are at historic highs during 2022 early seasonal disease. Companion posters presented at the 7th ReSViNET Conference, Respiratory Syncytial Virus Foundation, Lisbon, Portugal, February 2023.